I ACCEPT PAYPAL SHIPPING: Europe delivered time is 8 — 12 business days.
Usa/canada delivered time 15-20 business days.
Australia/Asia delivered time 15-26 business days.
For any possible questions, please, contact me! NEW 100 % ORIGINAL TRACKING NUMBER THANK YOU FOR VISITING MY LOT It is very important !!! Item will be shipped from Russia for 2-3 days and free shipping takes 14 to 21 days
NEW 100 % ORIGINAL
THANK YOU FOR VISITING MY LOT
Desloratadine 5 mg Excipients: calcium hydrophosphate dihydrate, microcrystalline cellulose, corn starch, talc. The composition of the shell: carnauba wax, white wax, film coating blue and transparent (lactose monohydrate, hypromellose, titanium dioxide, macrogol, aluminum blue lacquer FD & C No. 2 (indigocarmine, E132)). Pharmacological action Antihistamine is a long-acting drug, a blocker of peripheral histamine H1 receptors. Desloratadine is the primary active metabolite of loratadine. Inhibits a cascade of reactions of allergic inflammation, incl. Release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of pro-inflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, isolation of adhesion molecules such as P-selectin, IgE- Mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action, reduces permeability of capillaries, prevents the development of edema of tissues, spasm of smooth muscles. The drug has no effect on the central nervous system, has almost no sedative effect (does not cause drowsiness) and does not affect the rate of psychomotor reactions. Does not cause an extension of the QT interval on the ECG. The action of Erius begins within 30 minutes after ingestion and lasts for 24 hours. Pharmacokinetics Absorption After taking the drug, desloratadine is well absorbed from the gastrointestinal tract, with determined concentrations of desloratadine in the blood plasma reached within 30 minutes, and Cmax in about 3 hours Distribution The binding of desloratadine to plasma proteins is 83-87%. When used in adults and adolescents for 14 days in a dose of 5 mg to 20 mg 1 time / signs of clinically significant cumulation of desloratadine was not detected. Simultaneous food intake or simultaneous use of grapefruit juice does not affect the distribution of desloratadine (when taken at a dose of 7.5 mg 1 time /). Does not penetrate the BBB. Metabolism It is subjected to intensive metabolism by hydroxylation with the formation of 3-OH-desloratadine, combined with glucuronide. It is not an inhibitor of CYP3A4 and CYP2D6 and is not a substrate or an inhibitor of P-glycoprotein. Excretion Desloratadine is excreted from the body in the form of a glucuronide compound and in a small amount (less than 2% with urine and less than 7% with feces) unchanged.
Dosage Coated tablets Adults and adolescents aged 12 years and older are prescribed 5 mg 1 time /, regardless of food intake, preferably at the same time of day. The tablet should be swallowed whole, not liquid, squeezed with a small amount of water.