1d9655246edc69d2e3a1df614cba34ad - копия

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1d9655246edc69d2e3a1df614cba34ad - копия

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Pharmacodynamics Antiviral agent. Specifically suppresses in vitro influenza a and B viruses (Influenzavirus A, b), including highly pathogenic subtypes a(HINl)pdm09 and A(H5N1), as well as other viruses that cause acute respiratory viral infections (SARS) (coronavirus (Coronavirus) associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial Virus {Pneumovirus) And parainfluenza Virus (paramyxovirus)). According to the mechanism of antiviral action, it belongs to fusion inhibitors (fusions), interacts with the virus’s hemagglutinin and prevents the fusion of the virus’s lipid envelope and cell membranes. It has a moderate immunomodulatory effect, increases the body’s resistance to viral infections. It has interferon-inducing activity — in a study on mice, the induction of interferons was noted after 16 hours, and high titers of interferons were preserved in the blood up to 48 hours after administration. Stimulates cellular and humoral immune responses: increases the number of lymphocytes in the blood, especially T cells (CD3), increases the number of T-helper cells (CD4), without affecting the level of T-suppressors (CD8), normalizes the immunoregulatory index, stimulates the phagocytic function of macrophages and increases the number of natural killers (NK cells). Therapeutic effectiveness in viral infections is shown in reducing the duration and severity of the disease and its main symptoms, as well as in reducing the frequency of complications associated with viral infection and exacerbations of chronic bacterial diseases. In the treatment of influenza or SARS in adult patients in a clinical study it was shown that the effect of the drug Arbidol in adult patients is most pronounced in the acute period of the disease and is manifested by reducing the time of resolution of symptoms, decrease the severity of the disease and reduction of terms of eliminating the virus. Therapy with Arbidol leads to a higher frequency of relief of symptoms of the disease on the third day of therapy compared to placebo. 60 hours after the start of therapy, the resolution of all symptoms of laboratory-confirmed influenza is more than 5 times higher than in the placebo group. A significant effect of the drug Arbidol on the rate of elimination of the flu virus was found, which, in particular, was manifested by a decrease in the frequency of detection of RNA virus on the 4th day. It belongs to low-toxic drugs (LD50 > 4 g / kg). It does not have any negative effects on the human body when used orally in the recommended doses.

Dosage Inside, before meals. Single dose of the drug (depending on age): Age Children from 6 to 12 years — a Single dose of 100 mg (1 capsule) Children over 12 years and adults — a Single dose of 200 mg (2 capsules) dosage Regimen (depending on age): in children from 6 years and adults: non-Specific prevention during the flu epidemic and other acute respiratory infections — in a single dose 2 times a week for 3 weeks non-Specific prevention in direct contact with patients with flu and other SARS in a single dose 1 time a day for 10-14 days Treatment of flu and other SARS in a single dose 4 times a day (every 6 hours) for 5 days Complex therapy of recurrent herpetic infection in a single dose 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks Prevention of postoperative infections infectious complications in a single dose 2 days before surgery, then on the 2nd and 5th days after surgery in children from 6 years: Complex therapy of acute intestinal infections of rotavirus etiology in a single dose 4 times a day (every 6 hours) for 5 days, Use the drug only according to the indications, the method of use and in the doses specified in the instructions. Taking the drug begins with the appearance of the first symptoms of flu and other SARS, preferably no later than 3 days from the beginning of the disease. If after using the drug Arbi-Dol* for three days in the treatment of influenza and other SARS, the severity of symptoms of the disease remains, including a high temperature (38 °C or more), then you need to consult a doctor to assess the validity of taking the drug. In the treatment of influenza and SARS, concomitant symptomatic therapy is possible, including the use of antipyretic drugs, mucolytic and local vasoconstrictors.