4823002212761

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4823002212761

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dosage form
The solution is for intravenous administration.
Composition
1 ml of a solution containing anhydrous magnesium asparaginata — 40 mg (3.37 mg magnesium), anhydrous potassium asparaginata — 45.2 mg (10.33 mg potassium) acid «aspartic — 74 mg, heavy magnesium oxide in terms of 100% substance — 5.59 mg, of potassium hydroxide in terms of 100% substance — 14.82 mg;

Excipients:

Sorbitol — 50 mg Water for injections to 1 mL.
pharmachologic effect
Asparkam-Farmak eliminates electrolyte imbalance in the body, contributing to the penetration of potassium and magnesium ions in the intracellular space. The drug has a moderate antiarrhythmic properties, reducing the excitability of myocardial infarction several oppresses conductivity; reduces sensitivity to cardiac glycosides and reduces the manifestations of their toxicity.
Pharmacokinetics
Absorption — high. Excreted by the kidneys.
Side effects
Nausea, vomiting, diarrhea, dry mouth, discomfort or burning sensation in the pit of the stomach (in patients anatsidnyh gastritis or cholecystitis), abdominal pain, ulceration of the mucous membrane of the gastrointestinal tract, bleeding from the gastrointestinal tract, flatulence, dry mouth ; bradycardia, atrioventricular block, lowering blood pressure, a paradoxical response (increase in the number of premature beats), dyspnea, pruritus, hyperkalemia (nausea, vomiting, diarrhea, paresthesia), gipermagniemiya (redness of the face, thirst, lower blood pressure, hyporeflexia, respiratory depression, convulsions).

When injected, occasional nausea and dizziness, which usually take place by reducing the dose. Perhaps the development of phlebitis, thrombosis. With rapid intravenous — hyperkalemia, gipermagniemiya.

If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
sale Properties
prescription
Special conditions
Attention! With rapid intravenous can develop hyperkalemia and gipermagniemiya, with the occurrence of life-threatening arrhythmias of the patient, so the rapid intravenous administration of the drug is contraindicated!

If necessary, you can use the drug during pregnancy and lactation.

If necessary, Pharmak Asparkamom treatment can be combined with the use of cardiac glycosides and strophanthin. If necessary, the drug solution can be added to solutions of cardiac glycosides.

Injection is used in stationary and ambulatonyh conditions.

During treatment should refrain from road management or work with complex mechanisms.

Overdose.

With fast jet introduction or injection of the drug in doses that far exceed the therapeutic develop hyperkalemia (muscle hypotonia, paresthesia of limbs, slow atrioventricular conduction, arrhythmias, heart failure), gipermagniemiya that appears red face, thirst, pronounced decrease in blood pressure, disturbance neuromuscular transmission, depression of the respiratory center, arrhythmia, seizures.

Treatment: introducing calcium chloride or calcium gluconate, 10 ml of 10-40% (depending on overdoses of gravity), and implement measures to maintain respiratory function, hemodynamics. Symptomatic therapy. Perhaps hemodialysis or peritoneal dialysis.
testimony
To eliminate the deficiency (absolute or relative) of potassium and magnesium in the various manifestations of coronary heart diseases, including acute myocardial infarction; chronic circulatory failure; heart rhythm disturbances caused by the use of cardiac glycosides; massive diuretic therapy, vomiting, diarrhea, etc.
Contraindications
Hypersensitivity to the drug (including sorbitol and fructose), acute and chronic renal failure, hyperkalemia, atrioventikulyarnaya block I-III century., Myasthenia gravis, acute metabolic acidosis, gipermagniemiya, breach of amino acid metabolism, hypotension, dehydration (exsicosis) , hemolysis, Addison’s disease, a deficiency of fructose-1,6-difosfatazy, methanol poisoning.

Carefully.

To use caution:

— During pregnancy (especially the I trimester) and lactation;

— Cardiogenic shock (systolic blood pressure less than 90 mm Hg), hypophosphatemia, severe liver failure, metabolic acidosis, the risk of edema, chronic renal failure (if conducting regular monitoring Mg2 + concentration in the serum is not possible — the risk of accumulation).

Application of pregnancy and during breastfeeding.

To use caution during pregnancy (especially the I trimester) and lactation.
Drug interactions
While the use of potassium-sparing diuretics, ACE inhibitors, beta-blockers, cyclosporine, heparin, nonsteroidal anti-inflammatory drugs increase the risk of hyperkalemia (potassium level should be monitored in serum).

Asparkam-Farmak reduces sensitivity to cardiac glycosides.

Enhances negative dromo- and batmotroponoe action antiarrhythmics.

Eliminate hypokalemia caused by diuretics and corticosteroids.

General anesthetics increase the dampening effect on the central nervous system; while the use of atrakuroniem, decamethonium, succinyl and suksametoiiem may increase neuromuscular blockade.
Dosage
Enter intravenously or via a dosing device «Infuse» or intravenously (slowly). Intravenously administered 10-20 ml once or twice a day for 5 days. Before use, the contents of ampoules of 1.2 ml or 4.2 10 ampoules of 5 ml diluted in 100-200 ml 5% dextrose (glucose) or sterile 0.9% sodium chloride and administered dropwise at a rate of 20-25 drops per per minute, or the contents of one ampoule is diluted to 10 ml or 2 ml ampoules of 5 in 20 ml of 5% dextrose (glucose) or sterile 0.9% sodium chloride and injected into the vein of the jet at a speed of 5 ml per minute.