prodam-deksalgin--10c9-1470037614792285-1-big

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prodam-deksalgin--10c9-1470037614792285-1-big

 

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Dosage form The solution for intravenous and / or injection is clear, colorless, with a characteristic smell of alcohol. Composition 1 amp. Dexketoprofenum trometamol 73.8 mg, which corresponds to the content of dexketoprofen 50 mg. Auxiliary substances: ethanol 96% — 200 mg, sodium chloride — 8 mg, sodium hydroxide — up to pH 7.4, water d / u — up to 2 ml. Pharmacological action Non-steroidal anti-inflammatory drug (NSAID). Has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of COX-1 and COX-2. Analgesic effect occurs 30 minutes after parenteral administration. The duration of the analgesic effect after administration in a dose of 50 mg is 4-8 hours. With combined therapy with opioid analgesics of dexketoprofen, trometamol significantly (to 30-45%) reduces the need for opioids. Pharmacokinetics Absorption After intravenous administration of dexketoprofen, trometamol Cmax in the blood serum is achieved on average after 20 min (10-45 min). AUC after a single administration in a dose of 25-50 mg is proportional to the dose, both with the / m and with the / in the introduction. The corresponding pharmacokinetic parameters are similar after a single and repeated IM or IV injection, which indicates the absence of cumulation of the drug. Distribution For dexketoprofen, trometamol is characterized by a high level of binding to plasma proteins (99%). The average value of Vd is less than 0.25 l / kg, half-distribution time is about 0.35 h. Withdrawal The main way of eliminating dexketoprofen is its conjugation with glucuronic acid followed by excretion by the kidneys. T1 / 2 dexketoprofen trometamol is about 1-2.7 hours. Pharmacokinetics in special clinical cases. In elderly people, there is an increase in the duration of T1 / 2 (both after a single and after repeated IM or IV) on average to 48% And a decrease in the overall clearance of the drug

Dosage
Dexalgin® is for intravenous and / or intravenous administration. Recommended adult dose: 50 mg every 8-12 hours. If necessary, repeated administration of the drug with a 6-hour interval is possible. The daily dose is 150 mg. In elderly patients and patients with impaired liver and / or kidney function, Dexalgin® therapy should be started at lower doses; The daily dose is 50 mg. Dexalgin® is intended for short-term (no more than 2 days) use during acute pain syndrome. In the future, the patient can be transferred to analgesics for oral administration. Rules for the preparation and administration of solutions The contents of one ampoule (2 ml) are slowly injected deep in / m. The contents of one ampoule (2 ml) is administered by slow intravenous injection for at least 15 seconds. The contents of one ampoule (2 ml) are diluted in 30-100 ml of physiological solution, glucose solution or Ringer’s solution (lactate). The solution should be prepared under aseptic conditions and always protected from daylight. The diluted solution (should be clear) is administered by slow intravenous infusion for 10-30 minutes.