o_genuine-cerebrolysin-n10x1ml-vials-132c

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Product Description

o_genuine-cerebrolysin-n10x1ml-vials-132c

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Dosage Form

Solution for injection
Structure
1 ml of an aqueous solution containing 215.2 mg of the drug concentrate Cerebrolysin (complex peptides derived from porcine brain). Active fraction Cere presented peptides, molecular weight not exceeding 10 OOO daltons.

Excipients sodium hydroxide and water for Ying
Pharmacological action
Cere contains low molecular weight bioactive neuropeptides, which penetrate the blood-brain barrier and directly; come to the nerve cells. The drug has an organ multimodal action on the brain, t.e.obespechivaet metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.

a) metabolic regulation: Cerebrolysin improves aerobic energy metabolism of the brain, improves the intracellular protein synthesis in the developing and aging brain.

b) neuroprotection: Cerebrolysin protects neurons from the damaging effect of lactic acidosis, prevents the formation of free radicals, improves survival and prevents neuronal death in hypoxia and ischemia, reduces the damaging neurotoxic effects of excitatory amino acids (glutamate).

c) the neurotrophic activity: cerebrolysin — peptidergic nootropic the only drug with proven neurotrophic activity similar to natural causes neuronal growth (NGF), but manifests itself in terms of peripheral administration.

g) functional neuromodulation: Cerebrolysin has a positive effect in violation of cognitive functions, the processes of memorizing Pharmacokinetics

Cere complex composition, active fraction which consists of a balanced and stable mixture of biologically active oligopeptides having a total of multifunctional action, does not allow for normal pharmacokinetic analysis of individual components.
Pharmacokinetics
Cere complex composition, active fraction which consists of a balanced and stable mixture of biologically active oligopeptides having a total of multifunctional action, does not allow for normal pharmacokinetic analysis of individual components.
Side effects
Common side effects — more than 1/100 — less than 1/10; Rare side effects

— More than 1/1000 — less than 1/100; very rare side effects — more than 1/10000

— Less than 1/1000; Very rare side effects — less than 1/10000.

When excessively rapid introduction in rare cases can sense heat, sweating, dizziness, and (in rare cases) may palpitations or arrhythmia.

On the part of the gastrointestinal tract: in rare cases, loss of appetite, indigestion, diarrhea, constipation, nausea and vomiting

status epilepticus

CNS and peripheral nervous system: in rare cases, the intended effect of activation is accompanied by excitation (developing aggressive behavior, confusion, insomnia). There have been reports of the occurrence of a few cases

Immune system: very rarely observed hypersensitivity reactions or allergic reactions, manifested headache; by pain in the neck, legs, lower back; shortness of breath, chills and kollaptoidnye state.

Local reactions: In rare cases, there is redness, itching and burning at the injection site.
Features sale
prescription
Special conditions
When excessively rapid implementation of injections can sense heat, sweating, and dizziness. Therefore, the drug should be administered slowly.

Checking and confirming the compatibility of the preparation (within 24 hours at room temperature and in the presence of illumination) with the following standard infusion solutions: 0.9% sodium chloride solution, Ringer’s solution, 5% dextrose (glucose).

Allowed the simultaneous use of Cerebrolysin with vitamins and drugs, improves cardiac circulation, however, these drugs should not be mixed in the same syringe with Cerebrolysin.

Should not be mixed in the same solution for infusion Tserebrolizin® and balanced amino acid solutions.

Use only clear solution Cere and only once.

Effects on ability to drive and use machines

Clinical trials have shown that Tserebrolizin® not affect the ability to control the use of vehicles and machinery.
Testimony
Alzheimer’s disease, dementia syndrome of different genesis, chronic cerebrovascular insufficiency, ischemic stroke, traumatic injuries of the brain and spinal cord; mental retardation in children, hyperactivity and attention deficit disorder in children; in complex therapy — with endogenous

depression resistant to antidepressants.
Contraindications
idiosyncrasy of the drug;

acute renal failure;

status epilepticus;
Drug Interactions
Given the pharmacological profile of Cere should pay special attention to possible naaa additive effect with a joint appointment with antidepressants or MAO inhibitors. In such cases, it is recommended to reduce — dose antidepressant. Should not be mixed in the same solution for infusion Cere and balanced amino acid solutions.

Cere incompatible with solutions, which include lipids, and with solutions that change the pH (5.0-8.0). SPECIAL INSTRUCTIONS

When excessively rapid implementation of injections can sense heat, sweating, and dizziness. Therefore, the drug should be administered slowly. Tested and confirmed the compatibility of the drug (for 24 hours at room temperature and the presence of light) with the following standard solutions for infusion:

0.9% solution of sodium chloride (9 mg NaCI / ml).

Ringer’s solution (Na * — 153,98 mmol / l Ca2 + — 2.74 mmol / l K + — 4.02 mmol / l; SG — 163.48 mmol / l).
Dosage
Applied parenterally. Dose and duration of treatment depends on the nature and severity of the disease, and the age of the patient. Possible to assign single doses, which can reach a value of 50 ml, but it is more preferred to conduct the optimum treatment recommended course of treatment is daily injections for 10-20 days. • Acute conditions (ischemic stroke, cranio-cerebral trauma, complications of neurosurgical operations): from 10 ml to 50 ml • In the residual period of stroke and traumatic brain and spinal cord, from 5 ml to 50 ml • When psychoorganic syndrome and depression: from 5 ml to 30 ml • Alzheimer’s disease, vascular dementia and Alzheimer-combined vascular origin from 5 ml to 30 ml neyropediatricheskoy • In practice: 0.1-0.2 mL / kg body weight to enhance the effectiveness of treatment may be repeated course up until there is an improvement of the patient following treatment. After the first dose rate frequency assignment may be reduced to 2 or 3 times a week. Cerebrolysin used in the form of injections intramuscularly (5 mL), and intravenously (10 mL). Doses from 10 ml to 50 ml recommended only by slow intravenous infusion after dilution proposed standard solution for infusion. The duration of infusion is 15 to 60 minutes.