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Solution for injection amber, water, transparent.
* complex peptides derived from porcine brain 215.2 mg / ml
Other ingredients: sodium hydroxide, water d / and.
Tserebrolizin® contains low molecular weight bioactive neuropeptides, which penetrate the BBB and come directly to the nerve cells. Organ-specific drug has multimodal action on the brain, i.e. provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.
Metabolic regulation: the preparation Tserebrolizin® improves aerobic energy metabolism of the brain, improves the intracellular protein synthesis in the developing and aging brain.
Neuroprotective effect: the drug protects neurons from the damaging effect of lactic acidosis, prevents the formation of free radicals, improves perezhivayemost and prevents neuronal death in hypoxia and ischemia, reduces the damaging neurotoxic effects of excitatory amino acids (glutamate).
Neurotrophic Activity: drug Tserebrolizin® — peptidergic nootropic the only drug with proven neurotrophic activity similar to natural causes neuronal growth (NGF), but manifests itself in terms of peripheral administration.
Functional Neuromodulation: the drug has a positive effect in disorders of cognitive functions, improves concentration, memorization process.
Cere complex composition, active fraction which consists of a balanced and stable mixture of biologically active oligopeptides having a total of multifunctional action, does not allow for normal pharmacokinetic analysis of individual components.
When excessively rapid introduction: rarely — a sensation of heat, sweating, dizziness; in rare cases — tachycardia or fibrillation.
From the digestive system: rarely — loss of appetite, indigestion, diarrhea, constipation, nausea and vomiting.
CNS and peripheral nervous system: rarely — excitement, exhibit aggressive behavior, confusion, insomnia; in rare cases — grand mal seizures, convulsions.
Allergic reactions: In rare cases — hypersensitivity reactions manifested headache, pain in the neck, legs, lower back, shortness of breath, chills and kollaptoidnye state.
Local reactions: seldom — flushing of the skin, itching and burning at the injection site.
According to the results of clinical studies have reported the following side effects occur:
Cardio-vascular system: in rare cases — hypertension, hypotension.
CNS and peripheral nervous system: in rare cases — fatigue, tremor, depression, apathy, dizziness.
Other: in rare cases — hyperventilation, flu-like symptoms (cough, runny nose, respiratory tract infections).
Keep in mind that some unwanted effects (agitation, hypertension, hypotension, lethargy, tremors, depression, lethargy, dizziness, headache, shortness of breath, diarrhea, nausea) were identified during clinical trials and there were equally
When excessively rapid implementation of injections can sense heat, sweating, and dizziness. Therefore, the drug should be administered slowly.
Checking and confirming the compatibility of the preparation (within 24 hours at room temperature and in the presence of illumination) with the following standard infusion solutions: 0.9% sodium chloride solution, Ringer’s solution, 5% dextrose (glucose).
Allowed the simultaneous use of Cerebrolysin with vitamins and drugs, improves cardiac circulation, however, these drugs should not be mixed in the same syringe with Cerebrolysin.
Should not be mixed in the same solution for infusion Tserebrolizin® and balanced amino acid solutions.
Use only clear solution Cere and only once
Effects on ability to drive and use machines
Clinical trials have shown that Tserebrolizin® not affect the ability to control the use of vehicles and machinery.
— Alzheimer’s disease;
— A syndrome of dementia of various origins;
— Chronic cerebrovascular insufficiency;
— Ischemic stroke;
— Traumatic lesions of the brain and spinal cord;
— Mental retardation in children;
— Hyperactivity and attention deficit disorder in children;
— Endogenous depression resistant to antidepressants (in the complex therapy).
— Acute renal failure;
— Status epilepticus;
— Hypersensitivity to the drug.
With simultaneous use of Cerebrolysin with antidepressants or MAO inhibitors may enhance their mutual action. In such cases, it is recommended to reduce the dose of the antidepressant.
Tserebrolizin® incompatible with solutions, which include lipids, and with solutions that change the pH (5.0-8.0).
The drug should be administered parenterally. Dose and duration of administration depends on the nature and severity of the disease, and the age of the patient. Probably single administration at a dose of 50 ml, but more preferably for a course of treatment. The recommended course of treatment is daily injections for 10-20 days. To increase the effectiveness of treatment may be carried out before the repeated courses until improvement observed following treatment of the patient. After the first course of the frequency of injection may be reduced to 2 or 3 times a week. Tserebrolizin® used parenterally in the form of w / o Injection (5 ml) and the in / injection (10 ml). The drug at a dose of 10 ml to 50 ml recommended only by a slow / infusion after dilution standard solution for infusion. The duration of the infusions varies from 15 to 60 minutes. After opening the ampoule / vial of solution should be used immediately Cere