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Solution for injection amber, water, transparent.
* complex peptides derived from brain svini215.2 mg / ml
Excipients: Sodium hydroxide, water d / and.
Cerebrolysin contains low molecular weight biologically active neuropeptides, which penetrate the BBB and come directly to the nerve cells. Organ-specific drug has multimodal action on the brain, i.e. It provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.
Metabolic Regulation: drug Cerebrolysin improves aerobic energy metabolism of the brain, improves the intracellular protein synthesis in the developing and aging brain.
The neuroprotective effect: the drug protects neurons from the damaging effect of lactic acidosis, prevents the formation of free radicals increases perezhivayemost and prevents neuronal death in conditions of hypoxia and ischemia, reduces the damaging neurotoxic effects of excitatory amino acids (glutamate).
Neurotrophic Activity: drug Cerebrolysin — only peptidergic nootropic drug with proven neurotrophic activity similar to the action of natural neuronal growth factor (NGF), but manifests itself in a peripheral administration.
Functional Neuromodulation: the drug has a positive effect in cognitive dysfunction, improves concentration, memory processes.
The complex structure of Cere, active fraction which consists of a balanced and stable mixture of biologically active oligopeptides, having a total of multifunctional action, does not allow for normal pharmacokinetic analysis of the individual components.
When excessively rapid introduction: rarely — a feeling of heat, sweating, dizziness; in rare cases — tachycardia or fibrillation.
From the digestive system: rarely — loss of appetite, indigestion, diarrhea, constipation, nausea and vomiting.
From the central and peripheral nervous system: rarely — excitement, manifesting aggressive behavior, confusion, insomnia; in rare cases — grand mal seizures, convulsions.
Allergic reactions: In rare cases — hypersensitivity reactions manifesting headache, pain in the neck, legs, lower back, shortness of breath, chills and collaptoid state.
Local reactions: seldom — skin redness, itching and burning at the injection site.
According to the results of clinical studies have reported the following side effects occur:
Cardio-vascular system: in isolated cases — hypertension, hypotension.
From the central and peripheral nervous system: in isolated cases — fatigue, tremor, depression, apathy, dizziness.
Other: in rare cases — hyperventilation, influenza-like symptoms (cough, runny nose, respiratory tract infections).
Note that some unwanted effects (agitation, hypertension, hypotension, lethargy, tremors, depression, apathy, dizziness, headache, shortness of breath, diarrhea, nausea) were identified during clinical trials and there were equally
When excessively rapid implementation of injections possible feeling of heat, sweating and dizziness. Therefore, the drug should be administered slowly.
Checking and confirming the compatibility of the drug (for 24 hours at room temperature and in the presence of illumination) with the following standard infusion solution: 0.9% sodium chloride solution, Ringer’s solution, 5% dextrose (glucose).
Cere allowed simultaneous use with vitamins and drugs that improve heart circulation, but these preparations should not be mixed in the same syringe with Cere.
Do not mix in the same solution for infusion Cerebrolysin and balanced amino acid solutions.
Use only clear solution Cere and only once.
Effects on ability to drive vehicles and management mechanisms
Clinical trials have shown that Cerebrolysin not affect the ability to drive vehicles and the use of mechanisms.
— Alzheimer’s disease;
— A syndrome of dementia of various origins;
— Chronic cerebrovascular insufficiency;
— ischemic stroke;
— Traumatic injury of the brain and spinal cord;
— Mental retardation in children;
— Hyperactivity and attention deficit disorder in children;
— Endogenous depression resistant to antidepressants (in the complex therapy).
— Acute renal failure
— Status epilepticus;
— Hypersensitivity to the drug.
With simultaneous use of antidepressants or Cere with MAO inhibitors may enhance their mutual action. In such cases, it is recommended to reduce the dose of the antidepressant.
Cerebrolysin is incompatible with solutions which contain lipids and with solutions which change the pH (5.0-8.0).
The drug should be administered parenterally. The dose and duration of administration depend on the nature and severity of the disease and the patient’s age. Probably single administration at a dose of 50 ml, but it is more preferred to conduct the treatment. The recommended course of treatment is daily injections for 10-20 days. To increase the effectiveness of treatment can be repeated courses until there is improvement in the patient following treatment. After the first course of the frequency of injection may be reduced to 2 or 3 times a week. Cerebrolysin used parenterally in the form of w / o Injection (5 ml) and the I / injection (10 ml). The preparation at a dose of from 10 ml to 50 ml recommended only by a slow / infusion after dilution of standard solutions for infusion. The duration of the infusions varies from 15 to 60 minutes. After opening the ampoule / vial of the solution should be used immediately Cere