976619

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Product Description

976619

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Dosage Form

Diuretic Fast
The solution for the on / in and / m the introduction of transparent, colorless.
Composition
furosemid10 mg / ml

Excipients: sodium chloride, sodium hydroxide, water, etc. / and.
pharmachologic effect
Lasix — a diuretic quick action, a sulfonamide derivative. The mechanism of action related to the blockade of Lasix reabsorption of sodium ions and chloride in the ascending loop of Henle knee. The preparation influences the convoluted tubules, and this effect is associated with inhibition of carbonic anhydrase or antialdosterone activity. Lasix has a strong diuretic, natriuretic, hlorureticheskoe action. It increases excretion of potassium, calcium, magnesium.

When receiving the drug inside the top of diuretic effect is observed within the first hour, and the maximum effect is achieved within 1-2 hours after administration, duration of diuretic effect is 6-8 hours. When i / in the introduction of the beginning and the maximum diuretic effect observed respectively in 5 minutes and half an hour after administration, and its duration is about 2 hours. The on / in the introduction of Lasix causes varicose veins, quickly reducing preload, reducing the filling pressures of the left ventricle and pulmonary artery pressure. The drug reduces the systemic blood pressure.
Pharmacokinetics
When receiving the tablets inside Lasix bioavailability is 64%. The value of maximum blood plasma concentration of the drug increases with increasing dose, but the time does not achieve a maximum dose-dependent and varies widely depending on the condition of the patient. The half-life is approximately 2 hours. After the on / in the introduction of Lasix is ​​excreted in urine was significantly greater than after oral administration. The blood plasma drug is mainly due to the protein, mostly to albumin: in the concentration range from 1 to 400 ng / ml protein in contact with healthy individuals is 91-99%. Free fraction of 2.5-4.1% therapeutic concentrations. During drug biotransformation in the body it is converted mainly glucuronide
Side effects
From the water-salt metabolism and acid-base balance: long-term use or high doses — hypovolemia, dehydration, hypokalemia, hyponatremia, hyposalemia, alkalosis, in some cases — hypocalcemia.

Since the cardiovascular system: hypotension, cardiac arrhythmias.

On the part of the digestive tract: dry mouth, rarely — nausea, vomiting, diarrhea and in some cases — pancreatitis.

From the biochemical parameters and blood composition: transient hyperuricemia (gout with peaking) and increased urea and creatinine, in some cases — hyperglycemia and changes in the blood picture.

From the urinary system: deterioration in obstructive uropathy; in premature infants can nephrocalcinosis.

Skin: dermatitis.

From the senses: in some cases, the use of high doses of the drug and expressed violations of renal excretory function — hearing impairment, vision, paresthesia.

Other: dizziness, muscle weakness, seizures, and in some cases — anaphylactic shock.
sale Properties
prescription
Special conditions
Caution must be exercised with concomitant administration of Lasix and hypoglycemic drugs, as it may require dose correction last. If necessary, co-administration of Lasix and pressor amines must bear in mind the increased risk of side effects and reducing the effectiveness of both drugs.

Using the drug can not be excluded decline of attention, it’s important for people to drive and use machines.

During pregnancy, Lasix can be used only on strict and short time. Because the drug can get into breast milk (as well as inhibit lactation), breast-feeding should be discontinued, if necessary, its reception during lactation.
testimony
— Edema syndrome of different genesis (chronic heart failure IIB-III stages of cirrhosis of the liver — syndrome of portal hypertension, nephrotic syndrome);

— Renal failure;

— Acute left ventricular failure (cardiac asthma, pulmonary edema);

— Swelling of the brain;

— Arterial hypertension, including some forms of hypertensive crisis;

— Forced diuresis.
Contraindications
— Acute glomerulonephritis;

-terminal-stage renal disease;

— Hepatic coma;

— Diabetic coma;

— Violations of water-salt metabolism and AAR: hypokalemia, hyponatremia, hypovolemia, alkalosis;

— Hypersensitivity to sulfonamides.
Drug interactions
With simultaneous use of Lasix with cardiac glycosides increases the risk of glycoside intoxication, and in combination with glucocorticoid — the risk of hypokalemia. The drug potentiates the action curariform funds. When concomitant administration of Lasix with aminoglycosides or cephalosporins and cisplatin may increase their plasma concentrations, which may lead to the development of nephrotoxicity and ototoxic effects. Concomitant use of Lasix with lithium therapy may lead to increased reabsorption of lithium ions in the renal tubules and the appearance of toxic effects. NSAIDs may reduce the diuretic effect of Lasix. With simultaneous use of Lasix and other antihypertensives anti-hypertensive effect is potentiated
Dosage
Dosage is determined individually, taking into account the severity of violations of water-electrolyte balance, the value of glomerular filtration rate, severity of the patient’s condition. During treatment he corrected depending on the diuretic response and the general state dynamics. Inside Lasix is ​​usually assigned on an empty stomach. Parenteral drug prescribed to patients who can not receive oral medication, or in urgent cases. B / drug should be administered no faster than 1-2 minutes. With a mild hydropic syndrome initial dose for adults is generally 20-80 mg when taken orally and 20-40 mg / m or / in. When persistent swelling of the same or be increased by 20-40 mg (20 mg for parenteral administration) dose may be administered repeatedly not earlier than after 6-8 hours (2 hours for parenteral administration) until a diuretic effect. Such individually selected dose may be used one or two times a day (e.g., 8 and 14 h). Highest efficiency is achieved when taking 2-4 days a week preparation. For children, the initial dose is 2 mg / kg body weight (1 mg / kg — when administered parenterally). If an unsatisfactory effect it can be increased to 2.1 mg / kg (1 mg / kg — by parenteral administration) but no sooner than 6-8 hours after the previous use (for parenteral administration, this term is not less than 2 hours ). In arterial hypertension initial dose for adults is 80 mg / day (usually divided into two doses). It should match the patient’s condition. With little effect should be added to other antihypertensives. When pulmonary edema Lasix administered in / in a dose of 40 mg. If required by the patient, then after 20 minutes should perform another injection of 20 to 40 mg of Lasix.