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dosage form Capsules are pale yellow, with a gray inscription «Neurontin 300 mg» and «PD»; contents of capsules — a white or almost white powder Composition gabapentin300 mg
Excipients: lactose, corn starch, talc. pharmachologic effect Gabapentin is structurally similar to GABA, but its mechanism of action is different from others. Drugs interact with GABA-receptors (valproate, barbiturates, benzodiazepines, inhibitors of GABA-transaminase reuptake inhibitors GABA agonists, GABA prodrugs of GABA) and therapeutic concentrations did not bind to the following receptors (GABA and drunk and b, benzodiazepine, glutamate, glycine, and N-methyl-D-aspartate). In studies in vitro labeled gabapentin identified novel peptide receptors in rat brain tissue, including the neocortex and hippocampus, which may mediate the anticonvulsant activity of gabapentin and its derivatives (structure and function gabapentinovyh receptors are not fully understood). Side effects In the treatment of neuropathic pain
On the part of the body as a whole: not less than 1% — accidental injury, asthenia, back pain, flu syndrome, headache, infection, pain of various localization, peripheral edema, weight gain.
From the digestive system: at least 1% — constipation, diarrhea, dry mouth, dyspepsia, flatulence, nausea, vomiting, abdominal pain.
From the central and peripheral nervous system: at least 1% — gait disturbance, amnesia, ataxia, confusion, dizziness, hypesthesia, somnolence, abnormal thinking, tremor.
The respiratory system: not less than 1% — shortness of breath, sore throat;
Dermatological reactions: at least 1% — skin rash.
From the senses: not less than 1% — amblyopia.
In the treatment of partial seizures
Neurontin is most often used in combination with other anticonvulsants, so determine which drug caused side effects (if there was such a connection at all), it was impossible.
On the part of the body as a whole: not less than 1% — asthenia, malaise, face edema, fatigue, fever, headache, viral infection, peripheral edema, weight gain.
Since the cardiovascular system: at least 1% — vasodilation symptoms, or hypertension.
From the digestive system: at least 1% — flatulence, anorexia, gingivitis, abdominal pain, constipation, dental disease, diarrhea, dyspepsia, increased appetite sale Properties prescription Special conditions If necessary, reduce the dose or cancel the drug to replace it with an alternative drug should be gradually over a minimum of 1 week. Abrupt discontinuation of therapy with antiepileptic drugs in patients with epilepsy may provoke status epilepticus. Ineffective in the treatment of absence seizures. During pregnancy, it applies only if the expected benefit to the mother justifies the potential risk to the fetus (possibly slowing fetal growth in excess of the therapeutic dose of 3600 mg based on mg / m). Return with breast milk. His influence on infants breastfed unknown, so use in lactating women should be only if the benefit to the mother clearly outweighs the risk. The safety and efficacy of gabapentin destination for children up to 3 years as adjunctive therapy of epilepsy and in children under the age of 12 years have not been established as a monotherapy. The safety and efficacy of treatment of neuropathy in patients under the age of 18 years have not been established. In the case of adults somnolence, ataxia, dizziness, fatigue, nausea and / or vomiting, weight gain and drowsiness in children, hyperkinesia and hostility must stop treatment and consult a doctor. During the period of treatment must be careful when driving and other lesson. Potentially hazardous activities that require high concentration and psychomotor speed reactions. testimony — The treatment of neuropathic pain in adults aged 18 years and older;
— Monotherapy of partial seizures with secondary generalization and without adults and children over the age of 12 years;
— As an additional tool in the treatment of partial seizures with secondary generalization and without adults and children aged 3 years and older. Dosage Neurontin is prescribed orally with or without food, or with food. If you need to reduce the dose, stop the drug or replace it with an alternative means, it should be done gradually over a minimum of one week. In neuropathic pain in adults prescribed an initial dose of 900 mg / 3 receive equal doses; if necessary, depending on the effect of gradually increasing the dose until a maximum — 3.6 g / Treatment may start with a dose of 900 mg / (300 mg, 3 /), or within the first 3 days the dose may be increased gradually to 900 mg / by the following scheme 1 day — 300 mg 1 time /; Day 2 — 300 mg 2; Day 3 — 300 mg 3 If partial seizures for adults and children over the age of 12 years, the effective dose — 900 mg to 3.6 g / Therapy can be started with a dose of 300 mg 3 times a day for the first day and increased gradually to 900 mg for scheme described above. Subsequently, the dose may be increased to a maximum of 3.6 g / (divided into 3 equal doses). Was well tolerated in doses up to 4.8 g / maximum interval between doses at three receiving the drug should not exceed 12 hours in order to avoid the resumption of seizures. For children aged 3-12 years: initial dose varies from 10 to 15 mg / kg / dosing frequency — in 3 equal doses, to increase the effective dose is held for about 3 days. The effective dose of Neurontin in children aged 5 years and older is 25-35 mg / kg / dose equal to 3 divided doses. Neurontin effective dose for children aged 3 to 5 years is 40 mg / kg / dose equal to 3 divided doses. It marked good tolerability at doses up to 50 mg / kg / long-term use. The maximum interval between doses of the drug dose should not exceed 12 hours in order to avoid the resumption of seizures. There is no need to control the concentration of gabapentin in plasma. Neurontin may be used in combination with other anticonvulsant excluding changes in the plasma concentration or the concentration of other anticonvulsants in serum.