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For any possible questions, please, contact me! NEW 100 % ORIGINAL TRACKING NUMBER THANK YOU FOR VISITING MY LOT It is very important !!! Item will be shipped from Russia for 2-3 days and free shipping takes 14 to 21 days
NEW 100 % ORIGINAL
THANK YOU FOR VISITING MY LOT
Composition one cylinder (10 g) contains 8 g of active substance nitroglycerin 1% solution. Each tank contains at least 180 doses of 0.4 mg nitroglycerin per dose. Excipients: ethanol, propylene glycol. Pharmacological action of Nitroglycerin is an organic nitrogen-containing compound with a primary venodilation action. The EFFECTS of nitroglycerin are due to its ability to release nitric oxide from its molecule, which is a natural endothelial relaxing factor. Nitric oxide increases the intracellular concentration of cyclic guanosine monophosphate, which prevents the penetration of calcium ions into smooth muscle cells and causes their relaxation. The relaxation of smooth muscles of the vascular wall and causes vasodilation, which reduces venous return to heart (preload) and the resistance of the systemic circulation (afterload). This reduces heart function and myocardial oxygen demand. The expansion of coronary vessels improves coronary blood flow and promotes its redistribution in the area with reduced blood circulation, which increases oxygen delivery to the myocardium. Decrease of venous return leads to decrease of filling pressure, improvement of blood supply of subendocardial layers, decrease of pressure in a small circle of blood circulation and regression of symptoms at pulmonary edema. Nitroglycerin has a Central inhibitory effect on the sympathetic tone of blood vessels, inhibiting the vascular component of the formation of pain. Nitroglycerin also relaxes smooth muscle cells of the bronchi, urinary tract, gallbladder, bile ducts, esophagus, small and large intestine, as well as their sphincters. Action Nitromint® starts fast, the effect is within 1-1,5 min and lasts approximately 30 minutes. Pharmacokinetics Nitromint ® aerosol is rapidly and completely absorbed from the oral cavity into the systemic bloodstream. Bioavailability Nitromint® is 100% with sublingual intake, as it eliminates the «primary» hepatic degradation of the drug. The maximum concentration in blood plasma is reached in 4 minutes. Relationship with blood plasma proteins is 60%. Rapidly metabolized with nitrate reductase, with the formation of di-and mononitrates (active only isosorbide-5-Mononitrate), the final metabolite — glycerin. It is excreted by kidneys in the form of metabolites. Total clearance is 25-30 l/min After administration of the drug under the tongue half-life period from blood plasma is 2.5 to 4.4 minutes. Circulating nitroglycerin is strongly associated with erythrocytes and accumulates in the walls of blood vessels. The main way of removal of nitroglycerin-excretion of metabolites in the urine; less than 1% of the dose administered is excreted unchanged.
Dosage Is Sublingual. Before the first use of the container, fill the dosing pump by removing the protective cap and pressing the dosing valve several times before the spray. After prolonged use of the cylinder may be necessary to re-fill the pump. When using the cylinder should be kept vertically, spraying head up. Each press of the metering valve releases one dose (0.4 mg nitroglycerin) in the form of a spray from a container equipped with a mechanical pump. Shake the bottle before use is not necessary. For relief of angina attack-0,4-0,8 mg (1-2 doses), pressing the dosing valve, preferably in the sitting position, with breath holding at intervals of 30 seconds; then close your mouth for a few seconds. If necessary re-introduction, but not more than 1.2 mg (3 doses) for 15 min To prevent the development of seizure — 0.4 mg (1 dose) for 5-10 min before loading. In acute left ventricular failure, developing pulmonary edema-1.6 mg (4 doses) and more in a short period of time under strict control of blood circulation (systolic blood pressure should be above 100 mm Hg.art.). With insufficient therapeutic effect, the same dose can be repeated after 10 minutes. There is no need to change the dosage regimen when using the drug in elderly patients.