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For any possible questions, please, contact me! NEW 100 % ORIGINAL TRACKING NUMBER THANK YOU FOR VISITING MY LOT It is very important !!! Item will be shipped from Russia for 2-3 days and free shipping takes 14 to 21 days
NEW 100 % ORIGINAL
THANK YOU FOR VISITING MY LOT
dosage form The solution for the on / in the colorless or slightly greenish, transparent, without visible mechanical impurities. Composition potassium aspartate 45.2 mg
that corresponds to the content of K + 10.33 mg
40 mg magnesium aspartate
corresponding Mg2 + content of 3.37 mg
Excipients: water d / and. pharmachologic effect Agents acting on the metabolic processes. The source of potassium and magnesium ions.
Potassium and magnesium — intracellular cations that play a major role in the function of many enzymes, the interaction of intracellular structures and macromolecules, and in the mechanism of muscular contraction. Intra- and extracellular ratio of potassium ions, magnesium, calcium and sodium affect on myocardial contractility. Low levels of potassium ions and / or magnesium in the internal environment is able to provide proaritmogennoe action predisposes to the development of arterial gipertenzzii, atherosclerosis of the coronary arteries and the appearance of metabolic changes in myocardium.
One of the most important physiological functions is maintaining the potassium membrane potential of neurons, myocytes and other excitable myocardial tissue structures. The imbalance between intra- and extracellular potassium leads to a decrease in myocardial contractility, arrhythmia, tachycardia and increase the toxicity of cardiac glycosides.
Magnesium is a cofactor in more than 300 enzymatic reactions of energy metabolism and the synthesis of proteins and nucleic acids. Magnesium reduces stress reduction and heart rate, leading to a decrease in myocardial oxygen demand. Magnesium has anti-ischemic effects on myocardial tissue. Reduction of myocyte contractility of smooth muscle arterioles, including coronary leads to vasodilation and to increased coronary blood flow.
The combination of potassium and magnesium ions in a formulation based on the fact that potassium deficiency in an organism accompanied by magnesium deficiency often requires the simultaneous correction of both the content of ions in the body. At these levels simultaneously correcting electrolyte additive effect is observed, moreover, magnesium, potassium and reduce the toxicity of cardiac glycosides, without affecting their positive inotropic effect. Pharmacokinetics Suction
The ingestion of the drug absorption is high.
Return with urine.
Data on the pharmacokinetics of the drug in the form of a solution for the on / in is not available. Side effects The rapid on / in the introduction may develop hyperkalemia symptoms and / or gipermagniemii. sale Properties prescription Special conditions It should be used with caution to patients with an increased risk of hyperkalemia. In this case it is necessary to regularly monitor the level of potassium ions in the blood plasma.
Before taking this medication, the patient should consult a doctor.
The rapid on / in the introduction of the drug may develop skin redness.
Effects on ability to drive vehicles and management mechanisms
The drug does not affect the ability to drive and engage in activities that require high concentration and psychomotor speed reactions. testimony — In the complex therapy of heart failure, myocardial infarction, cardiac arrhythmias (especially ventricular arrhythmias);
— To improve the portability of cardiac glycosides; Contraindications — Acute and chronic renal failure;
— Oliguria, anuria;
— Addison’s disease;
— AV-block II and III level;
— Cardiogenic shock (blood pressure <90 mm Hg);
— Hypersensitivity to the drug Drug interactions While the use of potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs increased the risk of hyperkalemia until the appearance of arrhythmias and asystole. The use of potassium products in conjunction with corticosteroids eliminates hypokalemia caused by them. Under the influence of a decrease in potassium adverse effects of cardiac glycosides.
The drug increases the negative effects batmotroponoe dromo- and antiarrhythmic drugs.
Due to the presence of a preparation of potassium ions in the application Pananginum with ACE inhibitors, beta-blockers, cyclosporin, potassium-sparing diuretics, heparin, NSAIDs may develop hyperkalemia (potassium levels should be monitored in the blood plasma); with anticholinergics — more pronounced decrease intestinal motility; with cardiac glycosides — a decrease in their actions. Dosage The drug is administered in / in the drip, as a slow infusion. Single dose — 1-2 ampules, if necessary, may re-introduction after 4-6 hours To prepare the solution for i / v infusion contents 1-2 ampoules.. dissolved in 50-100 ml of 5% glucose solution. Overdose with a / in the introduction — hyperkalemia, gipermagniemiya; ingestion — a violation of cardiac conduction (especially in the current at the time of administration of pathology of cardiac conduction system).