o_panangin-n50-tab-5826

18.99$

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Product Description

o_panangin-n50-tab-5826

 

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Dosage Form

Tablets, film-coated
Composition
potassium asparaginate gemigidrat 166.3 mg,
which corresponds to the content of potassium asparaginata158 mg
magnesium asparaginate tetragidrat175 mg,
which corresponds to the content of magnesium asparaginata140 mg
Inactive ingredients: colloidal silicon dioxide, povidone, magnesium stearate, talc, corn starch, potato starch.
Composition of coating film: Macrogol 6000, titanium dioxide (E171), methacrylic acid copolymer (E 100%), talc
pharmachologic effect
Agents acting on the metabolic processes. The ion source of potassium and magnesium.
Potassium and magnesium — intracellular cations that play a fundamental role in the functioning of many enzymes, the interaction of intracellular structures and macromolecules, and in the mechanism of muscular contraction. Intra- and extracellular ratio of ions of potassium, magnesium, calcium and sodium affect on myocardial contractility. Low levels of potassium and / or magnesium in the internal environment can exert proaritmogennoe action predisposes to gipertenzzii arterial, coronary atherosclerosis and occurrence of metabolic changes in the myocardium.
One of the most important physiological functions potassium is to maintain the membrane potential of neurons, myocytes and other excitable myocardial tissue structures. Imbalance between intra- and extracellular potassium leads to a reduction of myocardial contractility, arrhythmia, tachycardia and increase the toxicity of cardiac glycosides.
Magnesium is a cofactor in more than 300 enzymatic reactions of energy metabolism and the synthesis of proteins and nucleic acids. Magnesium reduces stress reduction and heart rate, leading to a decrease in myocardial oxygen demand. Magnesium has anti-ischemic effects on myocardial tissue. Reduced myocyte contractility of smooth muscle walls of the arterioles, including coronary leads to vasodilation and to increased coronary blood flow.
The combination of potassium and magnesium ions in a formulation based on the fact that a deficiency of potassium in the body is often accompanied by a magnesium deficiency and requires simultaneous correction contents in the body of both ions. In the simultaneous correction of the levels of these electrolytes additive effect is observed, moreover, potassium and magnesium reduce the toxicity of cardiac glycosides, without affecting their positive inotropic effect.
Pharmacokinetics
Suction
The ingestion of the drug absorption is high.
Withdrawal
Excreted in the urine.
Data on the pharmacokinetics of the drug in the form of a solution for / in is not available.
Side effects
From the central and peripheral nervous system: paresthesia (due to hyperkalemia); hyporeflexia, seizures (caused gipermagniemiya).
Since the cardiovascular system: AV-block, a paradoxical response (increase in the number of premature beats), lower blood pressure; redness of the skin (due to gipermagniemiya).
From the digestive system: nausea, vomiting, diarrhea (in Vol. H. Due to hyperkalemia), discomfort or burning sensation in the area of ​​the pancreas (in patients with gastritis or cholecystitis anatsidnyh).
With the respiratory system: — respiratory depression (due gipermagniemiya).
Others: hot flashes (due gipermagniemiya).
Properties sale
No prescription required
Special conditions
It should be used with caution to patients with an increased risk of hyperkalemia. In this case it is necessary to regularly monitor the level of potassium ions in the plasma.
Before taking this medication, the patient should consult a doctor.
Effects on ability to drive vehicles and management mechanisms
The drug does not affect the ability to drive and to engage in activities that require high concentration and speed of psychomotor reactions.
Indications
— In the complex therapy of heart failure, myocardial infarction, cardiac arrhythmias (especially ventricular arrhythmias);
— To improve the portability of cardiac glycosides;
— Shortfall of potassium and magnesium in reducing their content in the diet (for tablets).
Contraindications
— Myasthenia gravis;
— AV-blockade of I degree;
— hemolysis;
— Infringement of amino acid metabolism;
— Acute metabolic acidosis;
— Dehydration.
Precautions should use the drug into the pregnancy (especially I trimester) and lactation (breastfeeding), I / O — at AV-blockade of I degree.
Drug Interactions
While the use of potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs increase the risk of hyperkalemia until the appearance of arrhythmias and asystole. The use of drugs in conjunction with potassium SCS eliminates hypokalemia caused by them. Under the influence of potassium, a decrease adverse effects of cardiac glycosides.
The drug increases the negative effects bathmotropic dromo- and antiarrhythmic drugs.
Due to the presence of the drug in the composition of potassium ions in the application Pananginum with ACE inhibitors, beta-blockers, cyclosporin, potassium-sparing diuretics, heparin, NSAIDs may develop hyperkalemia (requires monitoring of plasma potassium levels); with anticholinergics — more pronounced decrease intestinal motility; with cardiac glycosides — a decrease in their actions.
Dosage
Assign 1-2 tablets 3 maximum daily dose — 3 tablets 3 drug should be used after meals, because acidic environment of the stomach contents which reduces its effectiveness. The duration of treatment and the need for repeated courses of doctor determines individually