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dosage form Pills Composition Phenibutum 250mg;
Other ingredients: lactose, potato starch, calcium stearate pharmachologic effect Nootropic agent is a gamma-beta-Amino-phenylbutyric acid hydrochloride. Facilitates GABA-mediated neurotransmission in the CNS (direct effect on GABA-receptors) also has anxiolytic, psychostimulant, antiplatelet and antioxidant effects.
It improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral blood flow (increases the volume and the linear velocity of cerebral blood flow, reduces the tone of brain vessels, improves microcirculation, has antiplatelet effect). It helps reduce or disappearance of feelings of anxiety, tension, anxiety and fear, normalizes sleep, has some anticonvulsant effect.
No effect on choline and adrenergic receptors.
It extends the latent period and shortens the duration and severity of nystagmus.
Reduces the symptoms of fatigue and vasovegetative symptoms (including headache, a feeling of heaviness in the head, sleep disturbances, irritability, emotional lability), enhances mental performance.
It improves mental performance (attention, memory, speed and accuracy of sensory-motor reactions).
In exchange reception improves physical and mental performance, improves memory, normalizes sleep; It improves the condition of patients with movement and speech disorders. Patients asthenia from the first days of therapy improves well-being; It increases the interest and initiative (motivation activities) without the sedation and excitation. When applied after severe traumatic brain injury increases the number of mitochondria in the perifocal areas and improves during the bioenergetic processes in the brain.
When neurogenic lesions of the heart and the stomach normalizes the processes of lipid peroxidation. In the elderly does not cause congestion and excessive laxity, relaxing aftereffect often absent. It improves the microcirculation in the eye tissues, reduces the inhibitory effect of ethanol on the central nervous system. Low toxicity. Pharmacokinetics Absorption high, penetrates well into all tissues of the body and the BBB (brain tissue gets about 0.1% of the administered dose, with the young and the elderly to a greater extent). Evenly distributed in the liver and kidneys. It is metabolized in the liver — 80-95%, the pharmacologically inactive metabolites. Not accumulates. After 3 hours, the kidneys starts to separate, and the concentration in the brain tissue and is not reduced in the brain show a further 6 hours about 5% is excreted unchanged by the kidneys partially -. With bile Side effects CNS: increased irritability, agitation, anxiety, dizziness, headache, somnolence.
From the digestive system: nausea (during the first receptions).
Allergic reactions: skin rash, pruritus. sale Properties prescription Special conditions C caution in patients with erosive and ulcerative lesions of the gastrointestinal tract, liver failure.
With prolonged use it is necessary to monitor liver function and pattern of peripheral blood.
Ineffective when expressed phenomena of motion sickness (including uncontrollable vomiting, dizziness).
Effects on ability to drive vehicles and management mechanisms
In the period of treatment should refrain from potentially hazardous activities that require attention and speed of psychomotor reactions. testimony Asthenic and anxious-neurotic states, anxiety, fear, obsessive-compulsive disorder, psychopathy. Stuttering and tics in children with enuresis. Retention of urine in the background myelodysplasia. Insomnia and nightmares in the elderly. Prevention of anxiety disorders that arise before surgery and painful diagnostic studies (premedication).
Meniere’s disease, vertigo associated with dysfunction of the vestibular apparatus of various origins (including the otogennyh maze of vascular and traumatic disorders); Prevention of motion sickness when kinetoses.
Primary open-angle glaucoma (in combination therapy).
As adjunctive therapy in the treatment of alcoholism (and for the relief of psychopathological disorders in somatovegetativnyh withdrawal syndrome).
Treatment predelirioznyh and delirious states in alcoholism (in combination with conventional means of detoxication). Contraindications Hypersensitivity to Phenibut. Drug interactions It extends and enhances the effects of sleeping pills, narcotic analgesics, antiepileptic, antipsychotic and antiparkinsonian agents. Dosage Inside, regardless of meals. The dose, dosing frequency and duration of treatment depends on the indication, age of the patient tolerability. Adult dose ranges from 20 mg to 750 mg, for children — from 20 mg to 250 mg.