0e02c5e6def9d183f8e35ed7834e82e7

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Product Description

0e02c5e6def9d183f8e35ed7834e82e7

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NEW
100 % ORIGINAL

TRACKING NUMBER

THANK YOU FOR VISITING MY LOT

dosage form
The tablets covered with a cover of pink color, round, biconcave; seen in cross section two layers.
Composition
1 tab.

Trimetazidine dihydrochloride 20 mg

Excipients: corn starch, hydroxypropylcellulose (giproloza), magnesium stearate, lactose, talc.

shell composition: hypromellose (hydroxypropylmethylcellulose) plasdon, polyethylene glycol, talc, iron oxide red, titanium dioxide.
pharmachologic effect
It prevents the reduction in intracellular ATP content, ensures the normal functioning of membrane ion channels, transmembrane transport of potassium and sodium ions, and the preservation of cellular homeostasis.

Trimetazidine slows the oxidation of fatty acids by selective inhibition of the long-chain 3-CoA thiolase ketoatsetil, which leads to increased oxidation of glucose and the restoration interface between glycolysis and oxidative decarboxylation, and, as shown, protects the myocardium from ischemia. Switching fatty acid oxidation to glucose oxidation underlies trimetazidine antianginal actions.

In experimental studies on animals have shown that trimetazidine supports the energy metabolism of the heart and neurosensory organs during periods of ischemia; It reduces the amount of intracellular acidosis and extent of changes in transmembrane ion flow arising during ischemia; It lowers the level of the migration and infiltration of polynuclear neutrophils in ischemic and reperfusion of the heart tissue, reduces the size of myocardial damage; with no effect on hemodynamics.
Pharmacokinetics
Trimetazidine is rapidly and almost completely absorbed by the intestinal mucosa. Bioavailability is 90%. Cmax is reached within 2 hours and is (after a single oral administration of 20 mg of trimetazidine) about 55 ng / ml. Vd — 4.8 l / kg. Easily it passes through the blood-tissue barriers. Plasma protein binding is 16%.

T1 / 2 -. 4.5-5 hours excreted by the kidneys (60% — unchanged).
Side effects
Perhaps: allergic reactions (including skin rash, pruritus).

Rare: nausea, vomiting, gastralgia.
sale Properties
prescription
Special conditions
Trimetazidine does not affect the ability to drive a car and perform work requiring a high rate of psychomotor reactions.
testimony
Prolonged ischemic heart disease therapy: prevention of angina attacks (monotherapy or in combination therapy); cochle-treatment of vestibular disorders ischemic nature (including vertigo, tinnitus, hearing impairment); chorioretinal vascular disorders with an ischemic component.
Contraindications
Pregnancy, lactation (breastfeeding), increased sensitivity to trimetazidine.
Dosage
Take orally at a dose of 40-60 mg / multiplicity of receiving 2-3 Duration of therapy is determined individually, depending on the clinical situation.