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Composition Vinpocetine — 5 mg; Auxiliary. Islands in lactose, MCC, povidone K-25, magnesium stearate, sodium carboxymethyl starch pharmachologic effect The mechanism of action of vinpocetine is composed of several elements: it improves cerebral blood flow and metabolism, has a beneficial effect on the rheological properties of blood. The neuroprotective action is realized by reducing the adverse cytotoxic effect of excitatory amino acids. Improves the exchange of serotonin and norepinephrine in the brain, it stimulates the noradrenergic neurotransmitter systems and has an antioxidant effect. It improves the microcirculation in the brain by inhibiting platelet aggregation, reducing the pathologically increased blood viscosity, increase the deformability of red blood cells and the inhibition of the reuptake of adenoeina; promotes oxygen transfer into the cells by reducing the affinity of erythrocytes thereto. Selectively increases cerebral blood flow by reducing the cerebral vascular resistance without a significant impact on system performance circulatory (blood pressure (BP), cardiac output, heart rate, total peripheral vascular resistance); It does not cause the effect of «steal.» Pharmacokinetics Rapidly absorbed from the gastrointestinal tract, mainly its proximal. The maximum plasma concentration is reached within 1 hour. Therapeutic plasma concentration — 10-20 ng / ml. The bioavailability in the fasting — 7%, when administered to — about 60%. Easily penetrates the blood-tissue barriers (including the blood-brain, placental) tissue, breast milk. Contact with blood plasma proteins — 66%. Repeated receptions kinetics is linear.
Metabolized mainly in the liver. Some pharmacological activity of the metabolite has — apovinkaminovaya acid; gidroksivinpotsetin metabolites, gidroksiapovinkaminovaya acid digidroksivinpotsetin-glycinate — inactive.
Excreted by the kidneys and through the intestine in a ratio of 3: 2. The urine is released a few percent of the active ingredient in an unmodified form and the rest — in the form of metabolites. The half-life — about 5 hours. Side effects Since the cardiovascular system: ECG changes (depression ST, prolongation of QT interval), tachycardia, arrythmia, labile blood pressure, feeling the tides.
On the part of the central nervous system: sleep disorders (insomnia, excessive sleepiness), dizziness, headache, weakness, sweating.
From the digestive system: dry mouth, nausea, heartburn.
Skin allergic reactions. sale Properties prescription Special conditions In the presence of long QT syndrome, or concomitant use of drugs that provoke, prolongation of the interval QT, requires periodic monitoring of ECG.
The effect on the ability to drive the vehicle and operate machinery
Data on the effect of vinpocetine on the ability to control the car and the performance of work requiring speed of psychomotor reactions, no. testimony Neurology: symptomatic consequences of ischemic stroke therapy, vascular vertebrobaeilyarnoy insufficiency, vascular dementia, cerebral atherosclerosis, post-traumatic, ipertonicheskoy encephalopathy. Ophthalmology: chronic vascular diseases of the retina and choroid. Otology: hearing loss of perceptive type, Meniere’s disease, tinnitus. Contraindications Hypersensitivity to vinpocetine or other components of the preparation. Pregnancy and lactation. Children under the age of 18 went to (due to lack of clinical trial data) .Defitsit laktaey, lactose intolerance, malabsorption glyukoeogalaktoenaya (due to the presence of lactose in the composition of the drug). Drug interactions The interaction is not observed while the use of? Adrenoblokatorami (hloranolol, pindolol) Klopamid, glibenclamide, digoxin, acenocoumarol and hydrochlorothiazide, imipramine.
Simultaneous use of vinpocetine and methyldopa sometimes caused some increase in the hypotensive effect, so this treatment requires regular blood pressure control.
It increases the risk of hemorrhagic complications in the background of heparin.
Despite the lack of evidence supporting the possibility of interaction, it is recommended to be cautious while appointing a central drugs, antiarrhythmic and anticoagulation action. Dosage Inside, after a meal. The standard dose is 5-10 mg 3 times a day (15-30 mg / day). Dose adjustment in renal or hepatic function is required.